Untreated OSA and the impact on comorbidities and patient health

Treatment of OSA offers overall health benefits

Category: Sleep Health & Disorders , Treatment & Therapy
Topic: Comorbidities & Other Conditions, PAP Therapy & Adherence

OSA is a risk factor for the development or worsening of many other conditions, meaning that untreated OSA could have more consequences than just symptoms like daytime sleepiness—it could contribute to worse overall health and reduced life expectancy.

 

More than four of every five people with OSA have two or more comorbidities,1 and people with OSA who have any comorbidity are more than ten times more likely to die than those without comorbidities.2 The growing understanding of the relationship between comorbidities and OSA is reflected in the number of research papers on this topic, which has increased by more than fourfold over the last 20 years.1

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What are the most common comorbidities in patients with OSA?

The list of conditions that common in patients with OSA is long, and each condition can be made worse by OSA. These include obesity,3 hypertension,4 cardiovascular diseases,5 type 2 diabetes,6 depression,7,8 anxiety,8 and respiratory conditions like chronic obstructive pulmonary disorder (COPD) and asthma.9 Men with OSA often have diabetes and coronary artery disease, while hypertension and depression are more common in women.1,10

Treating OSA is about a good night’s sleep—and so much more

OSA is a chronic condition that needs long-term multidisciplinary management,11 and treating OSA is an important part of holistic patient care. As the leading treatment for moderate to severe OSA and an option for mild OSA, positive airway pressure (PAP) is highly effective at reducing or eliminating sleep-disordered breathing events from the first day of treatment. The protective effects of PAP appear to be particularly relevant in patients with comorbidities, are seen in older individuals.12-15

Beyond the symptomatic management of OSA, the patient benefits of PAP therapy include:

  • Decreased blood pressure and risk of cardiovascular events or disease16-18
  • Improved recovery after stroke19
  • Better control of blood glucose levels6
  • Improved mood and sleep quality20-21

These specific patient benefits also have positive impacts on health economics. Whether through PAP therapy, lifestyle changes, other medical interventions or a combination of these, the wide-ranging value of treating OSA underscores the significant role that effective management of this condition plays in enhancing overall health and quality of life.

Educating and encouraging patients is key

Many people may be unaware of the inter-relationship between OSA and other health conditions. This lack of awareness may influence their decision to focus on what feels like the more “critical” conditions, leaving their OSA untreated. Educating patients about the benefit of treating OSA on comorbidities can provide them with the opportunity to improve not just one, but two or more, conditions at the same time.

References:

1

Bonsignore MR, Baiamonte P, Mazzuca E, et al. Obstructive sleep apnea and comorbidities: a dangerous liaison. Multidiscip Respir Med 2019;14:8., https://mrmjournal.biomedcentral.com/articles/10.1186/s40248-019-0172-9

2

Chiang CL, Chen YT, Wang KL, et al. Comorbidities and risk of mortality in patients with sleep apnea. Ann Med 2017;49:377-83., https://mrmjournal.biomedcentral.com/articles/10.1186/s40248-019-0172-9

3

Meyer EJ, Wittert GA. Approach the Patient With Obstructive Sleep Apnea and Obesity. J Clin Endocrinol Metab 2023;109:e1267-e79., https://academic.oup.com/jcem/article/109/3/e1267/7284057

4

Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000;342:1378-84., DOI: 10.1056/NEJM20000511342190

5

Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation 2021;144:e56-e67., https://www.ahajournals.org/doi/10.1161/CIR.0000000000000988

6

Reutrakul S, Mokhlesi B. Obstructive Sleep Apnea and Diabetes: A State of the Art Review. Chest 2017;152:1070-86., https://doi.org/10.1016/j.chest.2017.05.009

7

Edwards C, Almeida OP, Ford AH. Obstructive sleep apnea and depression: A systematic review and meta-analysis. Maturitas 2020;142:45-54., https://doi.org/10.1016/j.maturitas.2020.06.002

8

Kim J-Y, Ko I, Kim D-K. Association of obstructive sleep apnea with the risk of affective disorders. JAMA Otolaryngol Head Neck Surg 2019;145:1020-6., doi:10.1001/jamaoto.2019.2435

9

Bouloukaki I, Fanaridis M, Testelmans D, et al. Overlaps between obstructive sleep apnoea and other respiratory diseases, including COPD, asthma and interstitial lung disease. Breathe 2022;18:220073., DOI:10.1183/20734735.0073-2022

10

Heinzer R, Marti-Soler H, Marques-Vidal P, et al. Impact of sex and menopausal status on the prevalence, clinical presentation, and comorbidities of sleep-disordered breathing. Sleep Med 2018;51:29-36., https://www.sciencedirect.com/science/article/abs/pii/S1389945718302983?via%3Dihub

11

Epstein LJ, Kristo D, Strollo PJ, Jr., et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 2009;5:263-76., https://doi.org/10.5664/jcsm.27497

12

Marrone O, Lo Bue A, Salvaggio A, et al. Comorbidities and survival in obstructive sleep apnoea beyond the age of 50. Eur J Clin Invest 2013;43:27-33., DOI:10.1111/eci.12011

13

Marotta AM, Borel JC, Galerneau LM, et al. Cardiovascular Events in Moderately to Severely Obese Obstructive Sleep Apnea Patients on Positive Airway Pressure Therapy. Respiration 2017;93:179-88., https://doi.org/10.1186/s40248-019-0172-9

14

Jennum P, Tønnesen P, Ibsen R, et al. Obstructive sleep apnea: effect of comorbidities and positive airway pressure on all-cause mortality. Sleep Med 2017;36:62-6., DOI:10.1016/j.sleep.2017.04.018

15

de Batlle J, Bertran S, Turino C, et al. Mortality in Patients Treated with Continuous Positive Airway Pressure at the Population Level. Am J Respir Crit Care Med 2018;197:1486-8., doi: 10.1164/rccm.201709-1889LE

16

Barbé F, Durán-Cantolla J, Sánchez-de-la-Torre M, et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA 2012;307:2161-8., doi:10.1001/jama.2012.4366

17

Marin JM, Agusti A, Villar I, et al. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA 2012;307:2169-76., doi:10.1001/jama.2012.3418

18

Pengo MF, Soranna D, Giontella A, et al. Obstructive sleep apnoea treatment and blood pressure: which phenotypes predict a response? A systematic review and meta-analysis. Eur Respir J 2020;55:1901945., https://doi.org/10.1183/13993003.01945-2019

19

Brill AK, Horvath T, Seiler A, et al. CPAP as treatment of sleep apnea after stroke: A meta-analysis of randomized trials. Neurology 2018;90:e1222-e30., DOI:10.1212/WNL.0000000000005262

20

Loredo JS, Ancoli-Israel S, Kim E-J, et al. Effect of continuous positive airway pressure versus supplemental oxygen on sleep quality in obstructive sleep apnea: a placebo-CPAP−controlled study. Sleep 2006;29:564-71., DOI:10.1093/sleep/29.4.564

21

Schwartz DJ, Kohler WC, Karatinos G. Symptoms of depression in individuals with obstructive sleep apnea may be amenable to treatment with continuous positive airway pressure. Chest 2005;128:1304-9., DOI:10.1378/chest.128.3.1304

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