More than four of every five people with OSA have two or more comorbidities,1 and people with OSA who have any comorbidity are more than ten times more likely to die than those without comorbidities.2 The growing understanding of the relationship between comorbidities and OSA is reflected in the number of research papers on this topic, which has increased by more than fourfold over the last 20 years.1
The list of conditions that common in patients with OSA is long, and each condition can be made worse by OSA. These include obesity,3 hypertension,4 cardiovascular diseases,5 type 2 diabetes,6 depression,7,8 anxiety,8 and respiratory conditions like chronic obstructive pulmonary disorder (COPD) and asthma.9 Men with OSA often have diabetes and coronary artery disease, while hypertension and depression are more common in women.1,10
OSA is a chronic condition that needs long-term multidisciplinary management,11 and treating OSA is an important part of holistic patient care. As the leading treatment for moderate to severe OSA and an option for mild OSA, positive airway pressure (PAP) is highly effective at reducing or eliminating sleep-disordered breathing events from the first day of treatment. The protective effects of PAP appear to be particularly relevant in patients with comorbidities, are seen in older individuals.12-15
Beyond the symptomatic management of OSA, the patient benefits of PAP therapy include:
These specific patient benefits also have positive impacts on health economics. Whether through PAP therapy, lifestyle changes, other medical interventions or a combination of these, the wide-ranging value of treating OSA underscores the significant role that effective management of this condition plays in enhancing overall health and quality of life.
Many people may be unaware of the inter-relationship between OSA and other health conditions. This lack of awareness may influence their decision to focus on what feels like the more “critical” conditions, leaving their OSA untreated. Educating patients about the benefit of treating OSA on comorbidities can provide them with the opportunity to improve not just one, but two or more, conditions at the same time.
Bonsignore MR, Baiamonte P, Mazzuca E, et al. Obstructive sleep apnea and comorbidities: a dangerous liaison. Multidiscip Respir Med 2019;14:8., https://mrmjournal.biomedcentral.com/articles/10.1186/s40248-019-0172-9
Chiang CL, Chen YT, Wang KL, et al. Comorbidities and risk of mortality in patients with sleep apnea. Ann Med 2017;49:377-83., https://mrmjournal.biomedcentral.com/articles/10.1186/s40248-019-0172-9
Meyer EJ, Wittert GA. Approach the Patient With Obstructive Sleep Apnea and Obesity. J Clin Endocrinol Metab 2023;109:e1267-e79., https://academic.oup.com/jcem/article/109/3/e1267/7284057
Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000;342:1378-84., DOI: 10.1056/NEJM20000511342190
Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation 2021;144:e56-e67., https://www.ahajournals.org/doi/10.1161/CIR.0000000000000988
Reutrakul S, Mokhlesi B. Obstructive Sleep Apnea and Diabetes: A State of the Art Review. Chest 2017;152:1070-86., https://doi.org/10.1016/j.chest.2017.05.009
Edwards C, Almeida OP, Ford AH. Obstructive sleep apnea and depression: A systematic review and meta-analysis. Maturitas 2020;142:45-54., https://doi.org/10.1016/j.maturitas.2020.06.002
Kim J-Y, Ko I, Kim D-K. Association of obstructive sleep apnea with the risk of affective disorders. JAMA Otolaryngol Head Neck Surg 2019;145:1020-6., doi:10.1001/jamaoto.2019.2435
Bouloukaki I, Fanaridis M, Testelmans D, et al. Overlaps between obstructive sleep apnoea and other respiratory diseases, including COPD, asthma and interstitial lung disease. Breathe 2022;18:220073., DOI:10.1183/20734735.0073-2022
Heinzer R, Marti-Soler H, Marques-Vidal P, et al. Impact of sex and menopausal status on the prevalence, clinical presentation, and comorbidities of sleep-disordered breathing. Sleep Med 2018;51:29-36., https://www.sciencedirect.com/science/article/abs/pii/S1389945718302983?via%3Dihub
Epstein LJ, Kristo D, Strollo PJ, Jr., et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 2009;5:263-76., https://doi.org/10.5664/jcsm.27497
Marrone O, Lo Bue A, Salvaggio A, et al. Comorbidities and survival in obstructive sleep apnoea beyond the age of 50. Eur J Clin Invest 2013;43:27-33., DOI:10.1111/eci.12011
Marotta AM, Borel JC, Galerneau LM, et al. Cardiovascular Events in Moderately to Severely Obese Obstructive Sleep Apnea Patients on Positive Airway Pressure Therapy. Respiration 2017;93:179-88., https://doi.org/10.1186/s40248-019-0172-9
Jennum P, Tønnesen P, Ibsen R, et al. Obstructive sleep apnea: effect of comorbidities and positive airway pressure on all-cause mortality. Sleep Med 2017;36:62-6., DOI:10.1016/j.sleep.2017.04.018
de Batlle J, Bertran S, Turino C, et al. Mortality in Patients Treated with Continuous Positive Airway Pressure at the Population Level. Am J Respir Crit Care Med 2018;197:1486-8., doi: 10.1164/rccm.201709-1889LE
Barbé F, Durán-Cantolla J, Sánchez-de-la-Torre M, et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA 2012;307:2161-8., doi:10.1001/jama.2012.4366
Marin JM, Agusti A, Villar I, et al. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA 2012;307:2169-76., doi:10.1001/jama.2012.3418
Pengo MF, Soranna D, Giontella A, et al. Obstructive sleep apnoea treatment and blood pressure: which phenotypes predict a response? A systematic review and meta-analysis. Eur Respir J 2020;55:1901945., https://doi.org/10.1183/13993003.01945-2019
Brill AK, Horvath T, Seiler A, et al. CPAP as treatment of sleep apnea after stroke: A meta-analysis of randomized trials. Neurology 2018;90:e1222-e30., DOI:10.1212/WNL.0000000000005262
Loredo JS, Ancoli-Israel S, Kim E-J, et al. Effect of continuous positive airway pressure versus supplemental oxygen on sleep quality in obstructive sleep apnea: a placebo-CPAP−controlled study. Sleep 2006;29:564-71., DOI:10.1093/sleep/29.4.564
Schwartz DJ, Kohler WC, Karatinos G. Symptoms of depression in individuals with obstructive sleep apnea may be amenable to treatment with continuous positive airway pressure. Chest 2005;128:1304-9., DOI:10.1378/chest.128.3.1304
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