Adaptive servo ventilation (ASV)* and sleep apnea

    Category: Treatment & Therapy
    Topic: PAP Therapy & Adherence

    Published date: March 26, 2025

    Research shows ASV* therapy delivers positive effects for the indicated population of patients with central sleep apnea (CSA) with additional benefits seen in specific patient groups.

    In the indicated patient population1-4

    Improved disease specific quality of life (QoL) based on SF 36† and Pichot Fatigue Scale

    In the indicated patient population1-4

    Reduced daytime sleepiness

    Frame 1000004762

    In addition to CSA, ASV*   treats obstructive sleep apnea (OSA) and treatment-emergent central sleep apnea (TECSA).

    Central sleep apnea (CSA)

    Prevalence:

    CSA

    Common symptoms: 6  
    • Insomnia
    • Poor quality of sleep
    • Sleep disturbances
    • Challenges concentrating
    • Morning headaches
    • Reduced ability to focus
    • Nocturnal angina
    • Paroxysmal nocturnal dispnoea

    Obstructive sleep apnea (OSA)

    Prevalence:

    OSA

    Common symptoms: 6  
    • Insomnia
    • Poor quality of sleep
    • Sleep disturbances
    • Mood changes
    • Cognitive deficits
    • Reduced ability to focus

    Treatment-emergent central sleep apnea (TESCA)

    Occurence:

    In patients with OSA when central apneas persist or emerge after obstructive events have been resolved by positive airway pressure (PAP therapy. In these patients, central events comprise more than 50% of remaining sleep disordered breathing events or lead to disruptive periodic breathing patterns.8-11  

    * ASV therapy should not be initiated in individuals with chronic and symptomatic heart failure (NYHA 2-4) with reduced LVEF≤45% and moderate-to-severe predominant CSA.

    † 36-Item Short Form Health Survey

    ‡ Pittsburgh Sleep Quality Index

    References:

    1

    Tamisier R et al. Analysis of impact on Pittsburgh sleep quality index in a wide spread of CSA treated with ASV: 6-month follow-up FACIL-VAA study results. ERJ 2022. doi:10.1183/13993003.congress-2022.4688

    2

    Arzt M et al. Effects of Adaptive Servo-Ventilation on Quality of Life: The READ-ASV Registry. Ann Am Thorac Soc. 2024 doi:10.1513/AnnalsATS.202310-908OC

    3

    Tamisier R et al. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort. Sleep Med. 2024doi:10.1016/j.sleep.2023.07.014

    4

    Tamisier R et al. Adaptive servo ventilation for sleep apnoea in heart failure: the FACE study 3-month data. Thorax. 2022 doi:10.1136/thoraxjnl-2021-217205

    5

    Donovan LM et al. Prevalence and Characteristics of Central Compared to Obstructive Sleep Apnea: Analyses from the Sleep Heart Health Study Cohort. Sleep 2016 doi:10.5665/sleep.5962

    6

    UpToDate: CSA pathogenesis: UpToDate

    7

    Benjafield AV et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019 doi:10.1016/S2213-2600(19)30198-5

    8

    Berger M et al. Treatment-emergent central sleep apnoea associated with non-positive airway pressure therapies in obstructive sleep apnoea patients: A systematic review. Sleep Med Rev. 2021 doi:10.1016/j.smrv.2021.101513

    9

    Kuzniar TJ et al. Treatment of complex sleep apnoea syndrome. Curr Treat Options Neurol. 2008 doi:10.1007/s11940-008-0036-7

    10

    Khan MT et al. Complex sleep apnoea syndrome. Sleep Disord. 2014 doi:10.1155/2014/798487

    11

    Wang J et al. Complex sleep apnoea syndrome. Patient Prefer Adherence 2013 doi:10.2147/PPA.S46626

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